Senior Scientist Guidehouse
Overview
Lead advanced laboratory research activities for the National Institute on Aging focusing on human taste organoid culture molecular biology bioinformatics animal research studies manuscript development and staff mentorship. Full-time position in Baltimore MD onsite requiring public trust clearance.
What You'll Do10
- 1Design and execute complex experiments evaluating hypotheses recommending new approaches updating SOPs ensuring reproducibility and aligning research with lab priorities
- 2Perform advanced data analysis using R and Python for proteomic transcriptomic epigenetic cDNA microarray RNAseq imaging and develop visualizations
- 3Develop and maintain novel 3D static and dynamic culture systems including hydrogel scaffolds bioreactors and microgravity culture methods
- 4Provide scientific leadership mentoring junior staff postdoctoral fellows trainees biologists and laboratory personnel on assay design microscopy HALO imaging software and advanced experimentation
- 5Manage laboratory operations equipment reagents frozen cell stocks animal samples and electronic notebooks supporting equipment cleaning validation runs and experimental planning
- 6Collaborate with NIA NIH and external investigators supporting animal protocols grant applications literature searches resource allocation reviews software coordination and weekly scientific updates
- 7Prepare technical reports manuscripts abstracts publications presentations literature reviews figures and scientific communications for internal groups peer-reviewed publications conferences and meetings
- 8Maintain clean compliant laboratory space while supporting daily equipment cleaning validation runs inspections experimental planning molecular biology methods model development data analysis and deliverables tied to daily research operations
- 9Capture incumbent candidate meeting labor category requirements without considering other qualifications
- 10Apply scientific theories techniques and judgment to research design evaluate findings and communicate results through reports presentations manuscripts publications and other scientific work products
Requirements12
- 1Ph.D. in Chemistry Biochemistry Biology Genetics Neuroscience or related field
- 2Minimum ten years advanced scientific expertise in molecular biology biochemistry cell culture 3D organoid culture human organoid media stem cell biology epigenetics aging disease states and related research techniques
- 3Proficiency with Python R Linux Microsoft Office Suite data management tools and bioinformatics approaches for cleaning curating analyzing interpreting reporting and visualizing large proteomics transcriptomics gene datasets
- 4Experience with advanced imaging live cell culture optical instrumentation small animal handling animal surgery tissue dissection and animal model systems
- 5Ability to apply scientific theories techniques and judgment to research design evaluate findings and communicate results through reports presentations manuscripts publications and other scientific work products
- 6Strong oral and written communication skills mentoring junior scientists postbaccalaureate staff visiting fellows technicians and laboratory personnel
- 7Must obtain and maintain Federal or DoD public trust clearance prior adjudication with Guidehouse
- 8Candidates with active public trust or suitability preferred
- 9Familiarity with HALO imaging software high-complexity image analysis HPLCs microanalytical balances centrifuges spectrophotometers vacuum apparatus optical microscopes and advanced live-cell imaging equipment
- 10Knowledge of human taste organoids taste stem cells metabolic disorders cancer-related taste research infectious disease models aging-related research and transcriptomic proteomic epigenetic cDNA microarray and RNAseq data
- 11Background coordinating laboratory resources protocols instrument scheduling databases biopsy inventories clinical samples de-identified participant data and related research documentation
- 12Demonstrated ability to mentor trainees support postbaccalaureate staff with graduate school preparation and present research at regional national and international scientific meetings
Salary Insight
$149 - $248k per year
Location
Required Skills
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