Senior Principal Scientist - Human Genetics Leadership

Overview

We seek a senior principal scientist to lead a Human Genetics laboratory driving translation of genetic insights into actionable hypotheses for target discovery. The ideal candidate will establish state-of-the-art experimental capabilities to functionally characterize human genetic variation while managing resources and execution across multiple projects. This role shapes genotype-to-phenotype strategies integrating rare variant genetics and advanced analytical approaches to inform target prioritization.

What You'll Do9

• 1Lead and develop a high-performing team of 2-3 wet lab scientists establishing state-of-the-art experimental capabilities to functionally characterize human genetic variation
• 2Manage resources priorities and execution across multiple projects ensuring high-quality data generation interpretation and delivery aligned with strategic goals
• 3Apply genetics expertise to enable recall-by-genotype strategies including participant identification from biobank resources and design of deep phenotyping protocols
• 4Evolve genotype-to-phenotype research strategy translating rare variants into biological hypotheses and target investment decisions
• 5Represent genetics expertise in cross-functional teams and governance boards contributing to portfolio prioritization alongside computational biology and disease area experts
• 6Build and maintain strong internal and external partnerships communicating scientific insights effectively to diverse audiences
• 7Mentor and develop scientists demonstrating proven people leadership skills influencing cross-functional teams in a matrix environment
• 8Connect clinical and/or biobank genetic data to biological mechanisms and therapeutic hypotheses across disease indications
• 9Drive innovation through curiosity for emerging technologies including AI-based approaches for variant interpretation and prioritization

Salary Insight