Senior Scientist Discovery Sciences Technologies Gilead
Overview
We seek a Senior Scientist to advance lipid nanoparticle technology within the LNP Center of Excellence and Discovery Sciences and Technologies department. This role drives innovation in mRNA-LNP therapeutics across virology oncology and inflammation areas. You will collaborate with internal research functions and external partners to translate discoveries into clinical development.
What You'll Do11
- 1Serve as in-house subject-matter expert on lipid chemistry and LNP formulation focusing on ionizable lipid chemistry and tissue-selective mRNA delivery.
- 2Provide scientific leadership in resolving complex delivery and formulation challenges.
- 3Drive design synthesis and evaluation of ionizable lipids and lipid libraries in partnership with internal and external collaborators.
- 4Design and optimize mRNA-LNP formulations and targeted architectures including ligand or conjugation strategies to meet project needs.
- 5Build and execute high-throughput LNP formulation and in vitro screening campaigns evaluating transfection efficiency cellular tropism immune activation and functional activity.
- 6Establish LNP purification characterization and discovery stage QC workflows such as particle size PDI zeta potential encapsulation efficiency and LC-based lipid/RNA analysis.
- 7Build strategic collaborations with academic groups technology vendors CROs and biotech partners communicating findings through reports presentations manuscripts and patent applications.
- 8Create Inclusion recognizing business value of diverse teams modeling inclusion and embedding diversity in team management.
- 9Develop talent understanding employee skills aspirations and potential coaching them on performance and future growth.
- 10Empower teams aligning goals purpose and organizational objectives holding them accountable and removing barriers.
- 11Lead scientific projects independently mentoring junior scientists in fast-paced matrixed environment.
Requirements8
- 1Ph.D. in pharmaceutical sciences chemistry chemical engineering bioengineering biochemistry or related discipline.
- 22+ years directly relevant experience after Ph.D. with demonstrated track record in LNP based nucleic acid delivery.
- 3Deep hands-on expertise in mRNA-LNP formulation and characterization including lipid selection composition optimization microfluidic or scalable mixing platforms DLS/PDI zeta potential encapsulation assays and LC-based lipid or RNA analysis.
- 4Hands-on expertise in LNP purification by tangential-flow filtration required.
- 5Experience designing systematic high-throughput or DoE-based formulation-screening campaigns integrating multi-parameter datasets into actionable delivery design rules.
- 6Demonstrated ability to lead scientific projects independently and mentor or manage junior scientists in fast-paced matrixed environment.
- 7Strong project management skills overseeing multiple projects simultaneously while maintaining high quality standards.
- 8Excellent verbal and written communication skills influencing and collaborating across disciplines presenting to executive leadership.
Salary Insight
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