Senior Scientist Translational Immunology Machine Learning Seismic Therapeutic
Overview
Lead translational immunology scientist driving biomarker discovery and proof-of-concept for autoimmune therapies. Partner with CROs and clinical sites to execute translational studies. Analyze complex immunological datasets from PBMC tissue biopsies serum plasma flow cytometry CyTOF single-cell RNA-seq cytokine profiling and multiplex immunoassays. Shape regulatory filings scientific publications and scientific strategy. Identify emerging technologies relevant to pipeline.
What You'll Do6
- 1Partner with external CROs and clinical sites to execute translational studies
- 2Oversee biomarker and bioanalytical assays PK and ADA development transfer and implementation in clinical setting
- 3Analyze and interpret complex immunological datasets from exploratory clinical samples including flow cytometry CyTOF single-cell RNA-seq cytokine profiling and multiplex immunoassays
- 4Contribute to regulatory filings clinical study reports and scientific publications
- 5Serve as scientific lead for immunology biomarker strategy representing translational science in cross-functional teams
- 6Identify and evaluate emerging technologies and assay platforms relevant to our pipeline
Requirements9
- 1Ph.D. Immunology or a closely related field
- 23-5+ years relevant experience in translational research with autoimmunity in an industry setting
- 3Fluent in bioanalytical assay development including transferring assays to CROs
- 4Hands-on experience with immunological assays flow cytometry mass cytometry ELISAs MSD multiplexed cytokine panels and transcriptomic methods
- 5Experience with GCP GLP environments and regulatory submissions IND BLA NDA
- 6Expertise with bioinformatics tools and analysis of high-dimensional datasets scRNA-seq CyTOF proteomics
- 7Deep working knowledge of human immunology including innate and adaptive immune pathways T cell biology B cell biology or innate immune signaling
- 8Demonstrated ability to analyze and communicate complex biological data to cross-functional audiences
- 9Strong publication record or equivalent evidence of scientific contribution
Salary Insight
$145 - $170k per year
Location
Required Skills
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