Senior Advisor Cardiovascular NAMs Investigative Toxicology
Overview
We seek a scientist to lead cardiovascular safety NAMs within Investigative Toxicology. This role anchors Lilly’s cardiovascular safety pillar, focusing on in vitro models to assess compound liabilities across cardiac and vascular biology. The ideal candidate will drive mechanistic insights and collaborate across functions to advance translational safety science.
What You'll Do8
- 1Develop expertise in human-relevant in vitro models for cardiovascular liability assessment, including hiPSC-CMs, hiPSC-ECs, 2D monolayer systems, 3D EHTs, cardiac organoids, and vessel-on-a-chip platforms.
- 2Design and execute mechanistic investigations into proarrhythmia, QT/AP prolongation, structural cardiomyopathy, mitochondrial cardiotoxicity, DIVI, and endothelial dysfunction.
- 3Implement electrophysiological and contractile readouts such as MEA recordings, calcium flux imaging, sarcomere assays, and impedance platforms while adopting emerging technologies within the CiPA framework.
- 4Apply 3D cardiovascular platforms for chronic dosing paradigms to capture structural and vascular injury endpoints beyond electrophysiology alone.
- 5Serve as primary scientific resource for project teams conducting cardiovascular in vitro studies and coordinate with in silico ADMET Intelligence for integrated decision frameworks.
- 6Evaluate cardiovascular NAMs technologies like multi-organ liver-heart MPS and AI/ML-assisted imaging, recommending platforms for adoption.
- 7Act as scientific liaison for CROs and academic partners, overseeing study design, data quality, and deliverables.
- 8Maintain awareness of regulatory developments, participate in consortia, and publish findings externally.
Requirements11
- 1PhD in Pharmacology Physiology Biomedical Engineering Toxicology or related field with training in cardiac vascular electrophysiology or biology.
- 2Advisor (R5): 2+ years postdoctoral or industry experience with advanced cardiovascular in vitro models.
- 3Senior Advisor (R6): 5+ years postdoctoral or industry experience leading independent scientific contributions and model qualification.
- 4Hands-on experience with hiPSC-CM differentiation, MEA-based proarrhythmia assessment, 3D EHT functional assessment, or endothelial/vessel-on-a-chip models.
- 5Ability to design experiments, manage concurrent projects, and prioritize under drug discovery timelines.
- 6Familiarity with CiPA paradigm ICH S7B/E14 Q&A framework or FDA ISTAND NAMs pathways.
- 7Strong written and oral communication skills demonstrated through publications or conferences.
- 8Experience operating in matrixed cross-functional environments.
- 9Knowledge of high-content imaging AI/ML phenotypic classification or transcriptomic profiling for mechanism-of-injury signatures.
- 10Exposure to cardio-oncology compound assessment using hiPSC-CM or EHT platforms evaluating electrophysiological and structural/mitochondrial toxicity.
- 11Mentoring junior scientists or leading embedded scientific activities.
Salary Insight
$126 - $205k per year
Location
Required Skills
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