billiontoone
billiontooneVerified Source

Clinical Genomics Scientist Oncology at BillionToOne

156K–177K
Partially · San Francisco, California
Posted July 29, 2026
payroll

Overview

Join a team of innovators in San Francisco to redefine molecular diagnostics. Drive somatic mutation variant interpretation and reporting while scaling reporting needs. This role transforms healthcare through precise diagnostics.

What You'll Do7

  • 1Perform somatic variant interpretation and data review by diving into literature and databases to classify variants and match treatments for reporting
  • 2Draft clinical reports using in-house reporting API while collaborating with engineering and QA teams
  • 3Develop interpretation and reporting policies aligned with ACMG/AMP guidelines and latest publications
  • 4Contribute to gene-level content curation focusing on domain and critical residue information
  • 5Serve as subject matter expert in molecular tumor boards presenting findings to facilitate knowledge sharing
  • 6Collaborate with R&D on somatic oncology projects providing expertise on variant interpretation and biological pathways
  • 7Assist with oncology R&D initiatives reviewing gene/variant-level analyses and biological mechanisms

Requirements5

  • 1Ph.D. in Human Genetics or related field with 2+ years experience in somatic variant interpretation
  • 2Experience with human mutation databases COSMIC ClinVar OncoKB dbSNP Genome browsers UCSC IGV BAM file analysis
  • 3Familiarity with cancer somatic mutation pathways and FDA approved drugs
  • 4Strong attention to detail following detailed SOPs and organizational skills for tracking clinical reporting
  • 5Excellent communication abilities for cross-functional collaboration

Salary Insight

$156 - $177k per year

Location

Typepartially
LocationSan Francisco, California

Required Skills

pythonawsreactkubernetesspark
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