Biophysical Characterization Engineer - SPR BLI at Medra
Overview
Scientist leads biophysical characterization on Medra Physical AI platform. Own label-free binding assays SPR BLI scaling autonomous workflows. Drive antibody affinity kinetics epitope binning self interaction quantitation. Collaborate with roboticists integrate multi instrument data partner with customers. Differentiate by blending deep biophysical judgment with hands-on automation expertise.
What You'll Do7
- 1Develop validate run SPR BLI assays across formats affinity kinetics epitope binning self interaction concentration quantitation on Carterra LSA Gator BLI
- 2Build biophysical capabilities end-to-end scope need evaluate technologies qualify instruments write SOPs prepare validated workflows for autonomous execution
- 3Partner with roboticists integrate manual SPR/BLI workflows into reliable high-throughput autonomous protocols sample handling plate setup sensor chip management data pipeline integration
- 4Create rigorous data analysis QC frameworks kinetics fitting binning heatmaps developability flags interpret results inform customer decisions
- 5Integrate biophysical data with orthogonal characterization thermal stability nanoDSF/DSC aggregation monomericity HPLC SEC DLS polyspecificity provide integrated developability picture
- 6Work directly with customers scope characterization campaigns communicate results translate scientific questions into executable assay plans
- 7Maintain rigorous ELN records drive reproducibility across every assay deployed
Requirements10
- 1Ph.D. biochemistry biophysics structural biology or B.S./M.S. with 6+ years hands-on industry experience
- 2Deep hands-on SPR BLI expertise instrument operation assay development data analysis avidity mass transport regeneration surface capacity fitting model selection
- 3Experience developing and qualifying biophysical assays from scratch method validation troubleshooting
- 4Understanding antibody structure function therapeutic antibody discovery developability process
- 5Strong documentation habits attention to detail drive multiple workstreams simultaneously
- 6Bonus: High-throughput SPR platforms Carnation LSA array-based epitope binning VHH bispecifics Fc-fusions non-Ig scaffolds
- 7Hands-on automation liquid handling platforms Lynx Tempest KingFisher
- 8Developability assay panels nanoDSF DSC HPLC SEC HIC AC-SINS integration multi instrument datasets
- 9Analysis pipelines scripting Python R for high-throughput kinetics data
- 10Track record developing qualifying new assays or platforms from scratch
Salary Insight
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